appetite thatquiets down
GLP-1 slows gastric emptying and signals fullness to the hypothalamus. most people notice smaller portions inside the first two weeks.
ODTHbA1cFDA-approved molecule
semaglutide
an orally dissolving tablet, once daily. no injection, no refrigeration.
- what you get
- semaglutide, orally dissolving tablet
- how you take it
- once daily, under the tongue
- dosing
- titrated to your labs, not a fixed schedule
- dispensed by
- a licensed US compounding pharmacy
- reviewed at
- week 12, against your own baseline
$149/mosee if you qualify
a physician decides what is right for you. if this is not a fit, your first panel is on us.
compounded by a licensed US pharmacy to your physician's prescription. compounded medications are not FDA-approved. the molecule is.
16.6%
average body weight lost at 64 weeks
against 2.7% on placebo. OASIS 4, oral semaglutide 25mg, 64 weeks
what this does for you
blood sugarthat steadies
fasting glucose usually moves first, often within four weeks. HbA1c follows across a quarter, and it is the one that misleads least.
muscle youhold on to
ferritin and albumin every month, because sharp caloric restriction takes protein and iron before it takes fat.
that trial tested the FDA-approved oral tablet. yours is the same molecule in a compounded sublingual form, which has not run a trial of its own. the pharmacology is well characterized; the delivery route is where the two differ. that is precisely why we read your response in your own labs rather than assume the trial average applies to you.
why we measure it, and what we are reading
a prescription without a follow-up draw is a guess with a receipt. every marker below has a direction we expect and a date we check it, and all of it is read against your own baseline rather than a population range.
HbA1cquarterly
reflects roughly three months of average glucose, so it moves last and misleads least. a fall of 0.3 to 0.5 points is a real metabolic response.
fasting glucosemonthly
usually the first marker to move, often inside four weeks.
fasting insulinmonthly
the earliest signal that insulin resistance is easing. rarely ordered outside research, which is why most people never watch it improve.
lipidsquarterly
triglycerides typically fall in proportion to weight lost. LDL is less predictable and occasionally rises.
ALT and ASTmonthly
elevated liver enzymes often normalize as hepatic fat clears. they double as the drug safety check.
ferritin and albuminmonthly
should hold steady. sharp caloric restriction costs iron and protein before it costs fat, and these two catch it early.
what happens, and when
before you start
a full fasting panel. nothing is prescribed until a physician has read it against your history.
baseline on every marker belowweeks 1 to 4
starting dose, same time each day. nausea, if it appears, appears now and usually settles within two weeks.
fasting glucose, ALT, ASTweeks 4 to 12
the dose escalates only if your labs and your tolerance both allow. we hold at the lowest effective dose rather than climbing to the maximum.
fasting insulin, lipids, ferritinweek 12
the review date, set before you start. your panel is read against your own baseline.
HbA1c and the full panelthis is a fit if
- your labs show insulin resistance, an elevated HbA1c, or raised liver enzymes
- your BMI is 30 or above, or 27 or above alongside a weight-related condition
- you want the metabolic picture, not only the number on the scale
- a monthly blood draw fits your life
this is not for you if
- you are pregnant, breastfeeding, or planning pregnancy within two months
- you or a first-degree relative have had medullary thyroid carcinoma, or you have MEN2
- you have a history of pancreatitis
- you have active gallbladder disease or significant gastroparesis
the detail
semaglutide is a GLP-1 receptor agonist. it mimics the gut hormone released after a meal, slowing gastric emptying and signaling satiety to the hypothalamus. yours is sublingual. it dissolves under the tongue and absorbs through the oral mucosa, bypassing the stomach. hold it until it dissolves, then no food or drink for fifteen minutes. appetite falls, portions shrink, weight follows. the clinically interesting question is what happens to your glucose handling, your liver and your lean mass while it does.
nothing here is offered before it is measured.
start my labsall treatments
- OASIS 4 trial, oral semaglutide 25mg in adults with overweight or obesity, 64 weeks. results reported 2025.
- FDA approval of oral semaglutide for weight management, 2025.
compounded medications are not FDA-approved and are prescribed at the discretion of a licensed physician. this page is information, not medical advice. prova does not replace your primary care provider.
